Apison, Tennessee. Home of a religious cult named The Temple of the Seven Stars located on what previously was a civil war battle ground. One of the members named Sidney rings up the FBI amid accusations of weapons stockpiling. This prompts the FBI to perform a raid on the place but no weapons are found and no members. Neither is Vernon Ephesian, the group's leader who believes very strongly in the subject of reincarnation.

Mulder, who was involved in the raid, suddenly has a odd urge to search the nearby field where he successfully locates an old Civil War bunker which contains six wives each about to commit suicide. One of the women, Melissa catches Mulder's attention as she feels like she has seen him before. The FBI take the women into custody but they are released within 24 hours of no trace of weaponry was found. Mulder and Scully go to interview Ephesian who turns out to be very uncooperative so instead they turn to Melissa. While interviewing her, Melissa suddenly shifts personalities into Sidney and starts talking exactly like him. Mulder is not convinced that this is just a case of Multiple Personality Syndrome and instead turns to the subject of reincarnation. He believes that Sidney is one of her past lives while Scully is extremely skeptical and can't understand why Mulder is so attracted to this one woman.

Then Melissa suddenly switches personality into another person, namely a Civil War nurse named Sarah Kavanaugh. Under her new personality she regresses about watching Sullivan Biddle, her fiancee, die in battle and suddenly Mulder realizes that this is one of his past lives which prompts him to be regressed himself much to the apprehension of the skeptical Scully.

Mulder regresses some very interesting stories involving Scully, Melissa, Cancer Man and many more characters that he has met in his lifetime while he tries hard not to cry. He also notes that Melissa and himself are always meant to be together. Melissa also listens to Mulder's story but is unable to believe so she returns to Ephesian. Scully, although skeptical, is not sure what to believe when she discovers old photographs and Sarah and Sullivan together.

Meanwhile, Ephesian leads his cult followers into a mass suicide. Mulder is too late as he bursts in only to find Melissa dead on the ground clutching the photo of Sarah in her grasp. Mulder is not sure what to believe.